KSM-66 Ashwagandha
300 mg in Ease · clinical-trial dose
Chandrasekhar 2012 — reduced serum cortisol 27.9%
The science
Trial-aligned doses. Linked to the paper.
Every ingredient in Repose is dosed at the amount the published clinical trial actually used — not the supplement-aisle minimum. Here's the math, the studies, and the why.
Affron Saffron
28 mg · the trial extract
Lopresti 2014 — effect comparable to first-line SSRIs
Myo-Inositol
15,000 mg in Still · Fux protocol
Fux 1996 — largest daily inositol dose on the consumer market
Lemon Balm Extract
100 mg in Ease · rosmarinic-acid extract
Kennedy 2002 — acute stress drop within 1–3 hours
The core problem
The supplement industry has a dose problem.
Open ten anxiety supplements. Read the labels. You'll find honest-sounding names — ashwagandha, magnesium, inositol, L-theanine — in doses that are a fraction of what the studies behind those names actually used.
It's not malicious. It's economic. Higher doses cost more per serving. The industry settled on amounts that fit in a capsule, look credible, and protect the margin. Then it borrowed the credibility of trials it never matched.
We do the opposite. We start with the trial. We meet the dose. Then we put it in a sachet because the dose doesn't fit in a capsule.
A side-by-side example: inositol for OCD
Typical supplement aisle
1 g
What most “OCD support” supplements contain per serving. Looks reasonable. Studied at 18× this amount.
Repose Still
15 g
What we ship. 83% of the Fux 1996 protocol dose. The largest daily inositol amount on the consumer market, by a wide margin.
How we built it
Every dose has a paper.
For each ingredient in Ease and Still, we identified the highest-quality published trial, sourced the form used in that trial, and matched (or came within 17% of) the daily amount. Where we deviated, we said so on the label and explained why.
Below is every active in both formulas, with the supporting study and the operational role in the body.
Ease
For panic & anxiety
A nervous-system threshold reset. Cortisol calm, GABA support, serotonergic baseline lift. Contains 5-HTP — not SSRI-friendly.
Myo-Inositol3,000 mg
Palatnik 2001, J Clin Psychopharm
Modulates serotonin receptor sensitivity. Studied for panic at higher doses (12g) but effective in lower amounts as part of a multi-component formula.
KSM-66® Ashwagandha300 mg
Chandrasekhar et al. (2012), Indian J Psychol Med
The KSM-66 extract at 300mg/day reduces serum cortisol meaningfully. The Chandrasekhar trial used 600mg/day for the largest reduction; we ship 300mg as a daily-tolerable dose.
L-Theanine400 mg
Williams et al. (2024), Nutrients
Acute calm with sustained alpha-wave activity. Reduced state anxiety within 60 minutes at 200–400mg. We dose at the upper end for stronger acute effect.
Magnesium Glycinate300 mg
Glycinate form for gentle absorption. NMDA modulation and HPA axis support. Higher than typical to support neuromuscular signalling depleted by sustained stress.
Affron® Saffron extract28 mg
Effect sizes for anxiety and low mood comparable to first-line SSRIs in meta-analysis (Lopresti, 2014). Standardised to 3.5% lepticrosalides.
5-HTP (Griffonia)100 mg
Maron 2004, Psychiatry Research
Direct precursor to serotonin. Supports mood regulation and the serotonergic component of panic dampening. Do not combine with SSRIs, SNRIs, MAOIs, or other serotonergic medications without explicit prescriber approval.
Passionflower Extract250 mg
Akhondzadeh 2001, J Clin Pharm Ther
GABA-A receptor modulation. The 2001 RCT showed effect comparable to oxazepam for generalised anxiety, without the sedation profile.
Lemon Balm Extract100 mg
Acute stress-response reduction within 1–3 hours (Kennedy et al. 2002). Standardised rosmarinic acid extract.
Vitamin B6 (P-5-P) + B12 (Methyl)25 mg + 500 mcg
Active forms. Required cofactors for serotonin and GABA synthesis. Methylcobalamin for the ~40% of the population with reduced cyanocobalamin conversion.
Still
For OCD & intrusive thoughts
A cortico-striatal loop brake. The Fux protocol with NAC, zinc and magnesium. SSRI-friendly.
Myo-Inositol15,000 mg
Fux et al. (1996), Am J Psychiatry · Levine 1997
The foundational OCD trial used 18g/day for six weeks. We ship 15g — 83% of the trial dose, the highest practical amount that still mixes cleanly in water. This is the formula's backbone.
N-Acetyl Cysteine (NAC)1,200 mg
Afshar et al. (2012), J Clin Psychopharm
Adjunctive NAC at 2,400mg/day reduced Y-BOCS scores when added to fluvoxamine. We ship 1,200mg as a daily-tolerable dose.
Magnesium Glycinate150 mg
NMDA modulation. Pairs with the glutamatergic mechanism NAC targets. Glycinate form for gut tolerance with the high inositol load.
Zinc Gluconate15 mg
Glutamate-NMDA modulation. Implicated in OCD-relevant glutamatergic dysregulation (Sayyah 2012). Gluconate form for absorption tolerance.
Vitamin B6 (P-5-P) + B12 (Methyl)25 mg + 500 mcg
Active forms. Required cofactors for neurotransmitter synthesis, including the inositol-dependent phosphatidylinositol cycle.
No 5-HTP · No St John's Wort · SSRI-friendly—
Nothing in Still drives serotonin synthesis. It doesn't stack with SSRIs in a way that triggers serotonin syndrome. We built Still specifically for people already on SSRIs whose loops never fully quieted.
What this doesn't mean
Honest about limits.
Dose precision does not equal a cure. Repose is not a treatment for panic disorder, generalised anxiety disorder, or OCD — those are clinical diagnoses that belong to clinicians.
What dose precision does mean: if you're already in therapy, already on an SSRI, already meditating, already exercising — and you want to add something that is doing the work of the published trial dose instead of one-tenth of it — Repose is that thing. If you're on an SSRI, choose Still (Ease contains 5-HTP).
The 60-day promise exists because we can't promise it will work for you specifically. If it doesn't, we refund. The mechanics are here.
Start where the trials started.
Two formulas. The clinical-trial doses. Mixed into water. Shipped to your kitchen table.
Plant-based nutrition to help the planet thrive
Repose products are 100% vegan, designed for low-carbon eating.